Basic Info.
Model NO.
food grade
Store
Dry
Botanical Source
Curcuma Longa Linn
CAS No.
458-37-7
M F
C21h20o6
M G
368.38
En No.
207-280-5
Transport Package
25kg/Drum
Specification
Food grade
Trademark
JK
Origin
China
HS Code
130239
Production Capacity
100mt/Year
Product Description
Description
Curcumin is the name given to a collection of compounds called curcuminoids, which are the active anti-inflammatory compound found in the super-spice turmeric.
Turmeric is the best known curry spice with brain benefits. This yellow, ginger-like plant plays an essential role in curry spice blends. A variety of studies using turmeric have suggested that it slows cognitive decline and benefits cognitive function. The challenge is that it is generally poorly absorbed, and the quantities needed to show a benefit are big, as in you'd need to eat about 3 heaping tablespoons of turmeric every day. When I lived and worked as a volunteer in various hospitals in India, including at a leprosarium near Calcutta, I likely ate this amount daily. That was when I ate curry- flavored meals for breakfast, lunch, and dinner.
Turmeric is the best known curry spice with brain benefits. This yellow, ginger-like plant plays an essential role in curry spice blends. A variety of studies using turmeric have suggested that it slows cognitive decline and benefits cognitive function. The challenge is that it is generally poorly absorbed, and the quantities needed to show a benefit are big, as in you'd need to eat about 3 heaping tablespoons of turmeric every day. When I lived and worked as a volunteer in various hospitals in India, including at a leprosarium near Calcutta, I likely ate this amount daily. That was when I ate curry- flavored meals for breakfast, lunch, and dinner.
Main Function
1. Turmeric extract mainly used as flavor additive to pigments and foods
2. Turmeric Extract has a good performances such as anticancer, anti,inflammatory antioxidation, antimutagenics, Lipoidemia reducing and etc.
3.Turmeric Extract used as a food coloring since it normally gives food (slightly yellow color) is used to protect food products from sunlight.
4. The curcumin/polysorbate solution or curcumin powder dissolved in alcohol is used for water-containing products. Over-coloring, such as in pickles, relishes, and mustard, is sometimes used to compensate for fading.
2. Turmeric Extract has a good performances such as anticancer, anti,inflammatory antioxidation, antimutagenics, Lipoidemia reducing and etc.
3.Turmeric Extract used as a food coloring since it normally gives food (slightly yellow color) is used to protect food products from sunlight.
4. The curcumin/polysorbate solution or curcumin powder dissolved in alcohol is used for water-containing products. Over-coloring, such as in pickles, relishes, and mustard, is sometimes used to compensate for fading.
Application Filed
| 1.Health food | |
| 2.Food additive |
| Curcumin Basic information |
| Product Name: | Curcumin |
| Synonyms: | Curcumin, AR;CURCUMIN, REAGENTCURCUMIN, REAGENTCURCUMIN, REAGENT;Curcumin, Curcuma longa L. - CAS 458-37-7 - Calbiochem;Liposomal Curcumin;Curcuimn;Curcumin pigment;CURCUMIN FROM CURCUMA LONGA CRYSTALL;Curcumin (mixture of curcumin |
| CAS: | 458-37-7 |
| MF: | C21H20O6 |
| MW: | 368.38 |
| EINECS: | 207-280-5 |
| Product Categories: | Miscellaneous Natural Products;Analytical Chemistry;Antioxidant;Biochemistry;Indicator (pH);pH Indicators;chemical reagent;pharmaceutical intermediate;Chalcone;Miscellaneous;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Diferuloylmethane, Natural Yellow 3, C.I. 75300;pigment;Colorants;Natural Plant Extract;Aromatics;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol File: | 458-37-7.mol |
| Curcumin Chemical Properties |
| Melting point | 183 °C |
| Boiling point | 418.73°C (rough estimate) |
| density | 0.93 |
| vapor density | 13 (vs air) |
| refractive index | 1.4155-1.4175 |
| Fp | 14ºC |
| storage temp. | ?20°C |
| solubility | ethanol: 10 mg/mL |
| form | powder |
| Colour Index | 75300 |
| pka | 8.09(at 25ºC) |
| color | orange |
| Odor | Odorless |
| PH Range | Yellow (7.8) to red-brown (9.2) |
| Water Solubility | Slightly soluble (hot) |
| λmax | 430nm |
| Merck | 14,2673 |
| BRN | 2306965 |
| Stability: | Stable, but may be light sensitive. Incompatible with strong oxidizing agents. |
| Major Application | Cosmetics, drug-eluting stents, inhibition of formation of skin-wrinkles, treating alzheimer's disease, skin diseases, coronary restenosis, diabetes, obesity, leukemia, neurofibromas, cancer, antimicrobial, antiviral, antiinflammatory, antiprostate cancer |
| InChIKey | VFLDPWHFBUODDF-FCXRPNKRSA-N |
| CAS DataBase Reference | 458-37-7(CAS DataBase Reference) |
| EPA Substance Registry System | Curcumin (458-37-7) |
| Safety Information |
| Hazard Codes | Xi,F |
| Risk Statements | 36/37/38-11 |
| Safety Statements | 26-36-16-7-37/39 |
| RIDADR | UN1170 - class 3 - PG 2 - Ethanol, solution |
| WGK Germany | 2 |
| RTECS | MI5230000 |
| Hazard Note | Irritant |
| TSCA | Yes |
| HazardClass | 3 |
| PackingGroup | II |
| HS Code | 29145000 |
| Hazardous Substances Data | 458-37-7(Hazardous Substances Data) |
| Toxicity | LD50 orally in Rabbit: > 5000 mg/kg |
| MSDS Information |
| Provider | Language |
|---|---|
| C.I. 75300 | English |
| Curcumin Usage And Synthesis |
| Chemical Properties | orange crystalline powder |
| Chemical Properties | Several species of Curcuma exist: C. xanthorrhyza, C. domestica, C. zedoafia, C. caesia and C. amada. Although all these are aromatic plants, C. longa is the one used as a flavor ingredient. The plant is originally from southern Asia and is widespread throughout India, Malaysia, Ceylon and Japan. It is a perennial herb whose rhizome yields (like that of ginger, which it also resembles) climbing stalks with leaves only or with leaves and flowers. Reproduction occurs through the splitting of the rhizome, which is the only part used (dried rhizome as is or after previously boiling in water). Turmeric has a spicy, fresh odor reminiscent of sweet orange and ginger and a slightly pungent, bitter flavor. |
| Uses | For preparing curcuma paper, pH range 8-9. In the detection of boron. |
| Uses | A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope. |
| Uses | antiedemic, antiinflammatory, bile stimulant; antibacterial, antifungal, lipo/cyclooxygenase inhibitor |
| Uses | Curcumin is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae). The curcuminoids are polyphenols and are responsible for the yellow color of turmeric. Curcumin can exist in at least two t |
| Definition | ChEBI: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa. |
| General Description | Orange-yellow needles. |
| Air & Water Reactions | Slightly soluble in hot water . |
| Reactivity Profile | Curcumin is sensitive to light and changes in pH. Curcumin may react with oxidizing materials. |
| Biological Activity | Antitumor, anti-inflammatory and antioxidant agent. Downregulates expression of reactive-oxygen-generating enzymes (cyclooxygenase, lipoxygenase, iNOS), TNF α , IL-1, IL-6, PKC, EGFR, NF- κ B, I κ B kinase and more. Upregulates expression of PPAR γ , p53, Nrf2. Also displays antimicrobial, antidiabetic neuro- and cardioprotective properties in vivo . |
| Anticancer Research | It is a yellow-colored polyphenolic compound found in turmeric and used as a foodadditive. It has antitumor effects involved in mutagenesis, cell cycle regulation,apoptosis, oncogene expression, and metastasis. Thus it regulates the initiation,promotion, and progression of disease (Hosseini and Ghorbani 2015). Its mechanismof action is diversified and convoluted. 10 μM curcumin suppresses binding of theTPA response element (TRE) by c-Jun/activator protein-1 in NIH 3 T3 cells ofmouse fibroblasts. Both protein kinase C and ornithine decarboxylase are alsoinhibited by curcumin. Inhibition of cyclooxygenase and lipoxygenase leads tosuppression of arachidonic acid cascade (Murakami et al. 1996). Curcumin is animpressive blocker of the activation of NF-κB by inhibiting IκB kinase (IKK).Curcumin also downregulates cyclin D1, suppresses the cell growth, and inducesapoptosis in prostate, breast, acute myelogenous leukemia, and multiple myelomacancer cells. It may act against psoriasis by inhibition of phosphorylase kinaseenzyme (Aggarwal and Shishodia 2004). Curcumin downregulates the TNF-inducedNF-κB-regulated gene products involved in cellular proliferation (cyclin D1, COX-2,c-myc), antiapoptosis (IAP2, IAP1, Bcl-2, XIAP, Bcl-xL, TRAF1, Bf1-1/A1,Cflip), and metastasis (MMP-9, , ICAM-1). It also suppresses the activity ofIκBα kinase, κBα degradation, IκBα phosphorylation, p65 nuclear translocation,p65 phosphorylation, and p65 acetylation (Aggarwal et al. 2008). It upregulates the expression of p53, p16, p21, EGR1 (early growth response protein1), ERK(extracellular signal-regulated kinase), JNK(c-Jun-N-terminal kinase), ElK1, Bax,and caspase 3, caspase8, and caspase9 proteins and downregulates Bcl2, mTOR,p65, Bcl-xL, AKT, EGFR, cdc2, retinoblastoma protein (Prb), c-myc, and cyclin D1proteins (Singh et al. 2016b). It can dissociate raptor from mTOR and inhibit mTORcomplex1. The inhibition of the Akt/mTOR signaling results from thedephosphorylation dependent on the calyculin A-sensitive protein phosphatase.Further, it modulating effect on AP-1 in HT-29 human colon cancer cells was foundto be a dose-dependent increase of AP-1 luciferase activity (Ravindran et al. 2009). Curcumin is a dynamic element of turmeric, an outstanding Indian zest that isobtained from the plant Curcuma longa dried roots. Curcumin hindered PDR-incitedproliferation of human hepatic myofibroblasts (Zheng and Chen 2006). Theactivated mechanism by curcumin in PGF signaling is as follows: Curcumindecreases the level of tyrosine phosphorylation of GFR-β and EGF-R; repressesthe action of ERK, JNK, and PI3/AKT; reduces cell growth; and induces apoptosisdose-dependently (Kunnumakkara et al. 2008). Moreover, curcumin interferes withPGF signaling via relieving its inhibitory effect on PPARγ gene expression toreduce the cell growth; it also promotes the expression of PPARγ genes (Zhou et al.2007). This compound is a yellow pigment produced by plants, mostly by those in theginger family (Zingiberaceae). Curcumin has enormous potential in terms of cancerprevention and treatment, and numerous studies and reviews described it as a potentantioxidant and anti-inflammatory agent (Aggarwal et al. 2003; Agrawal and Mishra2010). It inhibits biochemical activity, restraining overexpression of some signallingpathways and regulating the expression of tumour suppression genes (Cre?uet al. 2012). Temu kunci, or galangal (Boesenbergia pandurata), is a rhizome generallyused in cooking that can also be prepared to treat diarrhoea and mouth ulcers.It has been proven non-toxic to human skin fibroblast cells and offers protectiveeffects against colon cancer (Kirana et al. 2007). Turmeric (Curcuma longa) andginger (Zingiber officinale) are two plants that contain an abundance of curcuminand which have been investigated for their therapeutic properties. One piece ofresearch, for example, showed that ethanolic extract of turmeric showed anti-melanomaactivity against malignant melanomas (Danciu et al. 2015). |
| Purification Methods | Crystallise curcumin from EtOH or acetic acid. [Beilstein 8 IV 3697.] |
| Curcumin Preparation Products And Raw materials |
| Raw materials | Etanol-->Acetic anhydride-->Water-->2,4-Pentanedione-->Vanillin-->METHYL CHLORIDE-->1,2-Propanediol-->Butylamine-->Tributyl borate-->TURMERIC 1G [R]-->Curcuma oil-->Curcuma powder |
Hunan JK International Trade Corporation / JK BIO-CHEM CO.,LTD is a professional exporter of food/feed additives and food /feed ingredients in China. With years of development, now we are able to provide the following food additives and food ingredients: thickeners, antioxidants, preservatives, vitamins, sweeteners, proteins, acidulants, nutritional supplements, flavours, coenzyme and so on.
Our food additives and food ingredients, especially our Ascorbic Acid (Vitamin C), Acesulfame-K, Aspartame, Citrates, Dextrose, D-Xylose, Erythorbic Acid, Fumaric Acid, Fructose,Maltodextrin, Malic Acid, Monosodium glutamate, Lactic Acid Potassium Sorbate, Sodium Erythorbate, Sodium Cyclamate, Sodium Saccharin, sodium benzoate, Sodium ascorbate, Sorbic Acid, xanthan Gum, Xylitol, Tartaric Acid, I+G, , Vanillin, Sucralose, Stevia and so on, have been exported to more than 60 countries for our good quality products.
Our staff of sales and technical support is available to help you in selecting the right protection for your application as well as to provide you with samples of our products for evaluation. At High Five, we are committed to providing the highest level of customer service, competitive pricing, speedy delivery and a comprehensive, cutting-edge product offering. Our ultimate goal is your satisfaction.
Packing&Shipping
FAQ
Q1.What's the payment terms?
We could accept T/T, L/C, DP payment terms.
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Specifications can be customized according to your application.
Q3.How about the samples of products?
We can provide free samples under 2Kg(not including freight charge).
Q4.How about the price of products?
Our products are chemical synthesis got from underground brine, which is available for a variety of usage. Our products are high purity with good quality, and the price is based on different specification and quantity.
Q5.What's the shelf life for the cargoes?
Our product's shelf life is 2 years, which is based on dry and ventilated storage.
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20kg/25kg woven bags, within plastic bags, or as customized.
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We usually deliver the cargoes within 10~20 days after receiving customer's payment or original L/C.
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Commercial Invoice, Packing List, Certificate of Analysis, Certificate of Origin (FORM E), Bill of Loading, ISO etc.
The documents will be sent by Express within 24 hours against your full payment.
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